Griseofulvin constituents from marine fungus Y26-02

Objective To isolate and identify the chemical constituents of the ethyl acetate extract part of the marine fungus Y26-02 fermentation broth.Methods The compounds were isolated by silica gel column,Sephadex LH-20 column chromatography and HPLC techniques.And these compounds were identified by the physico-chemical properties and spectral analysis.Results Seven compounds were obtained and identified as griseofulvin(1),epigriseofulvin(2),isogriseofulvin(3),dechloroepigriseofulvin(4),dehydrogriseofulvin(5),4′-butoxyisogriseofulvin(6)and 2′-butoxyepigriseofulvin(7).Conclusions All mentioned compounds are firstly isolated from the fungus Y26-02.Compounds 6,7 are isolated from natural products for the first time.