银杏
药代动力学
吸收(声学)
银杏
药理学
医学
尿
银杏
分布(数学)
口服
胃肠道
药品
生物活性
生药学
传统医学
内科学
生物化学
化学
数学分析
体外
声学
物理
数学
作者
Moreau Jp,Eck Cr,James McCabe,Steven R. Skinner
出处
期刊:PubMed
日期:1986-09-25
卷期号:15 (31): 1458-61
被引量:6
摘要
The absorption, distribution and elimination of a radiolabelled 14C extract prepared from Ginkgo biloba leaves have been studied in rats. Following oral administration, expired 14C-CO2 represented 16% of the administered dose excreted within the first 3 hours post-dose out of a total of 38% after 72 hours. An additional 21% of the administered dose was eliminated in the urine. The absorption of the radiolabelled Ginkgo biloba extract was at least 60%. The pharmacokinetics of the drug, based on blood specific activity data versus time course, were characteristic of a two-compartment model with an apparent first order phase and a biological half-life of approximatively 4.5 h. During the first 3 hours, radioactivity was primarily associated with the plasma, but through a gradual uptake after 48 h. The specific activity in erythrocytes matched that of plasma. A site of absorption in the upper gastrointestinal tract is suspected since specific activity in blood peaked after 1.5 hours. Glandular and neuronal tissues and eyes showed a high affinity for the labelled substance. These results provide the first tentative link between the therapeutic effectiveness of Ginkgo biloba extract and the biological fate of some of its constituents.
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