Synthesis of γ-Lactam Catalyzed by 4A Molecular Sieve under Microwave Irradiation and Solvent Selection by Rough Set Theory

Chiral γ-lactam (pyrrolidinone) derivatives are a very important class of bioactive compounds that exist widely in the natural products, and they are versatile for the synthesis of drugs . We report here the synthesis of γ-lactams with high optical purity using molecular sieve as catalyst under microwave irradiation and the use of rough set theory (RST) , a recently developed computation method, to select the solvent for the cyclization reaction.