氮氧化物4
促炎细胞因子
氧化应激
NADPH氧化酶
活性氧
TLR2型
化学
血管紧张素II
炎症
肿瘤坏死因子α
下调和上调
受体
内分泌学
生物化学
生物
TLR4型
免疫学
基因
作者
Long Yue,Wang Wang,Yan Wang,Ting Du,Violet Shen,Huiling Tang,Ying Wang,Huiling Tang
标识
DOI:10.1016/j.ijbiomac.2016.05.002
摘要
In the current study, we analyzed the functions and mechanisms of Bletilla striata polysaccharide b (BSPb) against Angiotensin II (Ang II)-induced oxidative stress and inflammation in human mesangial cells (HMCs). It was found that BSPb could inhibit generation of Ang II-induced reactive oxygen species (ROS) and activation of proinflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in a dose-dependent manner. Further studies revealed that BSPb effectively blocked upregulation of NADPH oxidase 4 (NOX4). Moreover, knockdown of NOX4 significantly impaired the anti-oxidative function of BSPb. In addition, BSPb decreased overexpression of Toll-like receptor 2 (TLR2) induced by Ang II. Blocking TLR2 expression impaired the anti-inflammatory effects of BSPb. In conclusion, BSPb was found to possess anti-oxidative stress and anti-inflammatory functions against Ang II-induced ROS generation and proinflammatory cytokines activation. The NOX4 and TLR2 pathways played important roles in the biological effects mediated by BSPb.
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