错义突变
酪氨酸酶
外显子
眼白化病
遗传学
白化病
突变
生物
基因
分子生物学
酶
生物化学
作者
Richard A. King,Margaret M. Mentink,William S. Oetting
出处
期刊:PubMed
日期:1991-02-01
卷期号:8 (1): 19-29
被引量:58
摘要
Type I oculocutaneous albinism (OCA) is produced by mutations of the tyrosinase gene. We report four new missense mutations in the tyrosinase gene in patients with type IA OCA. Three of these mutations occur within exon I and the fourth mutation within exon IV. Analysis of the distribution of these four missense mutations and 12 previously reported missense mutations shows that most cluster in four areas of the gene. Two clusters involve the copper A and copper B binding sites and could disrupt the metal ion-protein interaction necessary for enzyme function. The other two clusters are in exon I and exon IV and could represent important functional domains of the enzyme. We conclude that analysis of the tyrosinase missense mutations will provide insight into the structure-function relationship of this enzyme.
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