计算生物学
计算机科学
电子线路
信使核糖核酸
比例(比率)
表达式(计算机科学)
基因
基因表达调控
基因表达
步伐
生物
吞吐量
遗传学
电信
工程类
物理
电气工程
量子力学
天文
无线
程序设计语言
作者
Harold D. Kim,Tal Shay,Erin K. O’Shea,Aviv Regev
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2009-07-24
卷期号:325 (5939): 429-432
被引量:162
标识
DOI:10.1126/science.1171347
摘要
Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.
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