生物
启动(农业)
C-C趋化因子受体6型
白细胞介素21
细胞毒性T细胞
抗原提呈细胞
抗原
CD40
CXCR3型
白细胞介素12
免疫学
T细胞
细胞生物学
免疫系统
体外
趋化因子
生物化学
植物
发芽
趋化因子受体
作者
Eva V. Acosta Rodríguez,Laura Rivino,Jens Geginat,David Jarrossay,Marco Gattorno,Antonio Lanzavecchia,Federica Sallusto,Giorgio Napolitani
摘要
Interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) have been characterized in mice as a distinct subset of effector cells, but their identity and properties in humans remain elusive. We report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORgammat, a transcription factor, whereas CCR6 and CXCR3 identified T(H)1 cells producing interferon-gamma and T helper cells producing both interferon-gamma and IL-17. Memory T cells specific for Candida albicans were present mainly in the CCR6+CCR4+ T(H)-17 subset, whereas memory T cells specific for Mycobacterium tuberculosis were present in CCR6+CXCR3+ T helper type 1 subset. The elicitation of IL-17 responses correlated with the capacity of C. albicans hyphae to stimulate antigen-presenting cells for the priming of T(H)-17 responses in vitro and for the production of IL-23 but not IL-12. Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens.
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