体内
细胞凋亡
胆囊
体外
黄芩苷
癌症研究
癌
线粒体
细胞生物学
化学
生物
医学
病理
内科学
生物化学
遗传学
高效液相色谱法
色谱法
作者
Yi-Jun Shu,Runfa Bao,Xiaoqing Wu,Hao Wu,Qi Ding,Yang Cao,Maolan Li,Jian Mu,Wenzhi Wu,Qichen Ding,Tianyu Li,Lin Jiang,Yunping Hu,Zhen Tan,Peng Wang,Yingbin Liu
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2014-02-23
卷期号:14 (8): 1136-1145
被引量:22
标识
DOI:10.2174/1871520614666140223191626
摘要
Baicalin, the main active ingredient in the Scutellaria baicalensis (SB), is prescribed for the treatment of various inflammatory diseases and tumors in clinics in China. In the present study, we evaluated the antitumor activity of baicalin for gallbladder carcinoma and the underlying mechanisms both in vitro and in vivo. Our results indicate that baicalin induced potent growth inhibition, cell cycle arrest, apoptosis and colony-formation inhibition in a dose-dependent manner in vitro. We observed inhibition of NF-κB nuclear translocation, up-regulation of Bax and down-regulation of Bcl-2, as well as increased caspase-3 and caspase-9 expression after baicalin treatment in vitro and in vivo, which indicates that the mitochondrial pathway was involved in baicalin-induced apoptosis. In addition, daily intraperitoneally injection of baicalin (15, 30 and 60 mg/kg) for 21 days significantly inhibited the growth of NOZ cells xenografts in nude mice, which improved the survival of baicalin-treated mice. In summary, baicalin exhibited a significant anti-tumor effect by suppressing cell proliferation, promoting apoptosis, and inducing cell cycle arrest in vitro, and by suppressing tumor growth and improving survival in vivo, which suggested that baicalin represents a novel therapeutic option for gallbladder carcinoma.
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