谷氨酸受体
甘氨酸
兴奋毒性
丝氨酸
氨基酸
麻醉
NMDA受体
医学
内科学
微透析
头部受伤
内分泌学
化学
受体
中枢神经系统
生物化学
外科
酶
作者
Alan M. Palmer,Donald W. Marion,Michelle L. Botscheller,David M. Bowen,Steven T. DeKosky
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:1994-12-01
卷期号:6 (1): 153-156
被引量:139
标识
DOI:10.1097/00001756-199412300-00039
摘要
THE concentrations of L-aspartate, L-glutamate, L-serine, glycine, and γ-aminobutyric acid (GABA) were determined in repeated samples of ventricular CSF from five patients with severe closed head injury. The values were compared with those obtained from five subjects undergoing surgical treatment for intractable depression. In the head-injured patients, the concentrations of aspartate, glutamate, and glycine were 2− to 8-fold higher, and the concentration of GABA 56− to 317-fold higher than control values; the concentration of serine was unaffected. Spearman correlation analysis indicated that the concentration of glutamate significantly increased after injury (Rs = 0.60, p < 0.0001, n = 42), reaching an average concentration of about 7 μM 3 days after the injury. This is probably sufficient to cause further excitotoxicity, which suggests the use of excitatory amino acid receptor antagonists as a treatment following severe head injury may require prolonged administration for maximum therapeutic benefit.
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