Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound

光学相干层析成像 医学 血管内超声 纤维帽 放射科 狭窄 冠状动脉粥样硬化 断层摄影术 心肌梗塞 心脏病学 冠状动脉疾病 病理
作者
Ik‐Kyung Jang,Brett E. Bouma,Dong-Heon Kang,Seung‐Jung Park,Seong‐Wook Park,Ki‐Bae Seung,Kyu-Bo Choi,Milen Shishkov,Kelly Schlendorf,Eugene Pomerantsev,Stuart Houser,H. Thomas Aretz,Guillermo J. Tearney
出处
期刊:Journal of the American College of Cardiology [Elsevier]
卷期号:39 (4): 604-609 被引量:974
标识
DOI:10.1016/s0735-1097(01)01799-5
摘要

The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients. Disruption of a vulnerable coronary plaque with subsequent thrombosis is currently recognized as the primary mechanism for acute myocardial infarction. Although such plaques are considered to have a thin fibrous cap overlying a lipid pool, imaging modalities in current clinical practice do not have sufficient resolution to identify thin (<65 μm) fibrous caps. Optical coherence tomography is a new imaging modality capable of obtaining cross-sectional images of coronary vessels at a resolution of approximately 10 μm. The OCT images and corresponding histology of 42 coronary plaques were compared to establish OCT criteria for different types of plaques. Atherosclerotic lesions with mild to moderate stenosis were identified on angiograms in 10 patients undergoing cardiac catheterization. Optical coherence tomography and intravascular ultrasound (IVUS) images of these sites were obtained in all patients without complication. Comparison between OCT and histology demonstrated that lipid-rich plaques and fibrous plaques have distinct OCT characteristics. A total of 17 IVUS and OCT image pairs obtained from patients were compared. Axial resolution measured 13 ± 3 μm with OCT and 98 ± 19 μm with IVUS. All fibrous plaques, macrocalcifications and echolucent regions identified by IVUS were visualized in corresponding OCT images. Intimal hyperplasia and echolucent regions, which may correspond to lipid pools, were identified more frequently by OCT than by IVUS. Intracoronary OCT appears to be feasible and safe. Optical coherence tomography identified most architectural features detected by IVUS and may provide additional detailed structural information.
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