化学
还原(数学)
酮
组合化学
有机化学
药物化学
几何学
数学
作者
Tamás Patonay,Károly Micskei,Éva Juhász‐Tóth,Szabolcs Fekete,Veronika Cs. Pardi-Tóth
出处
期刊:Arkivoc
日期:2009-05-01
卷期号:2009 (6): 270-290
被引量:9
标识
DOI:10.3998/ark.5550190.0010.627
摘要
Comparative experiments on the selective reduction of α-azido ketones to α-amino ketones revealed that tin(II) chloride reduction followed by immediate protection with Boc group is the method of choice.This methodology proved to be useful for more complex substrates, too.Chromium(II) acetate also resulted in the desired products but in lower yields due to a competitive deazidation procedure.A mechanism to explain this deazidation was suggested.
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