代谢组学
代谢物分析
代谢物
仿形(计算机编程)
色谱法
化学
计算生物学
计算机科学
生物
生物化学
操作系统
作者
Georgios Theodoridis,Helen Gika,Ian D. Wilson
标识
DOI:10.1016/j.trac.2008.01.008
摘要
In order to perform metabonomic investigations, it is necessary to generate comprehensive “global” metabolite profiles from complex samples, such as biofluids and tissues/tissue extracts. Analytical technologies based on liquid chromatography coupled to mass spectrometry (LC-MS) are destined to become a major source of global metabolite profiling data. Here, we describe and compare the utility of various analytical strategies and techniques currently used for LC-MS (capillary, high-performance and ultra-performance). We describe current challenges in the application of LC-MS-based techniques for metabonomic analysis.
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