克里唑蒂尼
癌症研究
医学
间变性淋巴瘤激酶
肺癌
后天抵抗
碱性抑制剂
铈替尼
基因重排
酪氨酸激酶
抗药性
肿瘤科
内科学
生物
基因
遗传学
癌症
受体
恶性胸腔积液
作者
Ryohei Katayama,Alice T. Shaw,Tahsin M. Khan,Mari Mino‐Kenudson,Benjamin Solomon,Balázs Halmos,Nicholas A. Jessop,John C. Wain,Alan T. Yeo,Cyril H. Benes,Lisa Drew,Jamal C. Saeh,Katherine Crosby,Lecia V. Sequist,A. John Iafrate,Jeffrey A. Engelman
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2012-02-08
卷期号:4 (120)
被引量:1227
标识
DOI:10.1126/scitranslmed.3003316
摘要
Multiple mechanisms of crizotinib resistance were identified in lung cancer patients including new secondary ALK mutations and activation of receptor tyrosine kinases.
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