摘要
British Journal of DermatologyVolume 117, Issue 4 p. 419-428 Type I and III collagen content and fibre distribution in normal human skin during ageing C.R. LOVELL, Corresponding Author C.R. LOVELL Department of Dermatology, Royal United Hospital, BathDr C.R.Lovell, Department of Dermatology, Royal United Hospital, Combe Park, Bath BA13NG U.K.Search for more papers by this authorK.A. SMOLENSKI, K.A. SMOLENSKI Agricultural and Food Research Council, Institute of Food Research, Bristol Laboratory, Langford, Bristol, AvonSearch for more papers by this authorV.C. DUANCE, V.C. DUANCE Agricultural and Food Research Council, Institute of Food Research, Bristol Laboratory, Langford, Bristol, AvonSearch for more papers by this authorN.D. LIGHT, N.D. LIGHT Agricultural and Food Research Council, Institute of Food Research, Bristol Laboratory, Langford, Bristol, AvonSearch for more papers by this authorS. YOUNG, S. YOUNG Division of Anatomy, United Medical and Dental Schools of Guy's and St Thomas Hospitals, Guy's Campus, London, U.K.Search for more papers by this authorM. DYSON, M. DYSON Division of Anatomy, United Medical and Dental Schools of Guy's and St Thomas Hospitals, Guy's Campus, London, U.K.Search for more papers by this author C.R. LOVELL, Corresponding Author C.R. LOVELL Department of Dermatology, Royal United Hospital, BathDr C.R.Lovell, Department of Dermatology, Royal United Hospital, Combe Park, Bath BA13NG U.K.Search for more papers by this authorK.A. SMOLENSKI, K.A. SMOLENSKI Agricultural and Food Research Council, Institute of Food Research, Bristol Laboratory, Langford, Bristol, AvonSearch for more papers by this authorV.C. DUANCE, V.C. DUANCE Agricultural and Food Research Council, Institute of Food Research, Bristol Laboratory, Langford, Bristol, AvonSearch for more papers by this authorN.D. LIGHT, N.D. LIGHT Agricultural and Food Research Council, Institute of Food Research, Bristol Laboratory, Langford, Bristol, AvonSearch for more papers by this authorS. YOUNG, S. YOUNG Division of Anatomy, United Medical and Dental Schools of Guy's and St Thomas Hospitals, Guy's Campus, London, U.K.Search for more papers by this authorM. DYSON, M. DYSON Division of Anatomy, United Medical and Dental Schools of Guy's and St Thomas Hospitals, Guy's Campus, London, U.K.Search for more papers by this author First published: October 1987 https://doi.org/10.1111/j.1365-2133.1987.tb04921.xCitations: 177AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat SUMMARY The content of type I and III collagen in normal human skin from subjects of different ages was studied by means of a new high performance liquid chromatography method and by SDS-polyacrylamide gel electrophoresis and scanning electron microscopy. The ratio of types I and III collagen in covered skin remained constant throughout childhood and young adult life and the proportion of type III was shown to be the same as previously reported. However, in the elderly, the proportion of type III collagen in the dermis increased to a variable degree. Scanning electron microscopic examination showed a decrease in the number of collagen fibre bundles with age. Average bundle width varied significantly with age. These results may reflect an impaired synthesis of type I collagen in aged skin. Citing Literature Volume117, Issue4October 1987Pages 419-428 RelatedInformation