Mouse model of membranous nephropathy induced by cationic bovine serum albumin: antigen dose-response relations and strain differences

Background. Few well-characterized animal models have been developed to study the pathogenesis of membranous nephropathy (MN). We have developed a mouse model of MN induced by cationic bovine serum albumin (cBSA), and examined the role of genetic background on disease induction by assessing different mouse strains.