已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals

医学 无症状的 放射科 胰腺 胰管 磁共振成像 导管内乳头状粘液性肿瘤 胰腺癌 内科学 内镜超声 囊肿 发育不良 胃肠病学 癌症
作者
Marcia I. Canto,Ralph H. Hruban,Elliot K. Fishman,Ihab R. Kamel,Richard D. Schulick,Zhe Zhang,Mark Topazian,Naoki Takahashi,Joel G. Fletcher,Gloria M. Petersen,Alison P. Klein,Jennifer E. Axilbund,Constance A. Griffin,Sapna Syngal,John R. Saltzman,Koenraad J. Mortelé,Jeffrey Lee,Eric P. Tamm,Raghunandan Vikram,Priya Bhosale,Daniel Margolis,James J. Farrell,Michael Goggins
出处
期刊:Gastroenterology [Elsevier BV]
卷期号:142 (4): 796-804 被引量:596
标识
DOI:10.1053/j.gastro.2012.01.005
摘要

The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neoplasms, but the optimal imaging approach is not known. We determined the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals (HRIs).We screened 225 asymptomatic adult HRIs at 5 academic US medical centers once, using computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasonography (EUS). We compared results in a blinded, independent fashion.Ninety-two of 216 HRIs (42%) were found to have at least 1 pancreatic mass (84 cystic, 3 solid) or a dilated pancreatic duct (n = 5) by any of the imaging modalities. Fifty-one of the 84 HRIs with a cyst (60.7%) had multiple lesions, typically small (mean, 0.55 cm; range, 2-39 mm), in multiple locations. The prevalence of pancreatic lesions increased with age; they were detected in 14% of subjects younger than 50 years old, 34% of subjects 50-59 years old, and 53% of subjects 60-69 years old (P < .0001). CT, MRI, and EUS detected a pancreatic abnormality in 11%, 33.3%, and 42.6% of the HRIs, respectively. Among these abnormalities, proven or suspected neoplasms were identified in 85 HRIs (82 intraductal papillary mucinous neoplasms and 3 pancreatic endocrine tumors). Three of 5 HRIs who underwent pancreatic resection had high-grade dysplasia in less than 3 cm intraductal papillary mucinous neoplasms and in multiple intraepithelial neoplasias.Screening of asymptomatic HRIs frequently detects small pancreatic cysts, including curable, noninvasive high-grade neoplasms. EUS and MRI detect pancreatic lesions better than CT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
LYSM应助shangjiaGuo采纳,获得30
2秒前
3秒前
3秒前
Akim应助科研通管家采纳,获得10
4秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
4秒前
我是老大应助科研通管家采纳,获得10
5秒前
英俊的铭应助科研通管家采纳,获得10
5秒前
情怀应助科研通管家采纳,获得30
5秒前
5秒前
7秒前
大模型应助干净又晴采纳,获得10
7秒前
mellow发布了新的文献求助10
7秒前
YCG完成签到 ,获得积分10
7秒前
Amon发布了新的文献求助10
8秒前
称心嫣娆发布了新的文献求助10
9秒前
爆米花应助淡定采纳,获得10
10秒前
洞两完成签到,获得积分10
12秒前
13秒前
Akim应助俏皮的白柏采纳,获得10
13秒前
13秒前
16秒前
bkagyin应助一颗椰子糖耶采纳,获得10
18秒前
天天快乐应助露露采纳,获得10
18秒前
干净又晴发布了新的文献求助10
19秒前
20秒前
20秒前
wkjfh应助Leoniko采纳,获得10
21秒前
帅男发布了新的文献求助10
22秒前
wyp发布了新的文献求助10
23秒前
24秒前
子非鱼发布了新的文献求助10
24秒前
26秒前
阿氏之光发布了新的文献求助10
29秒前
烟花应助自由的读书人采纳,获得10
29秒前
酷炫抽屉完成签到 ,获得积分10
29秒前
30秒前
露露发布了新的文献求助10
30秒前
congenialboy发布了新的文献求助10
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531914
关于积分的说明 11255516
捐赠科研通 3270597
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190