自愈水凝胶
乙二醇
生物相容性
药物输送
PEG比率
高分子
纳米颗粒
化学工程
肿胀 的
毒品携带者
化学
纳米技术
控制释放
材料科学
流变仪
光漂白后的荧光恢复
聚合物
高分子化学
有机化学
膜
生物化学
经济
财务
工程类
作者
Matthias Henke,Fabian Brandl,Achim Goepferich,Jörg Teßmar
标识
DOI:10.1016/j.ejpb.2009.08.011
摘要
Hydrogels play an important role in drug delivery and tissue engineering applications due to their excellent biocompatibility and their variable mechanical and physical properties, which allow their optimization for many different aspects of the intended use. In this study, we examined the suitability of poly(ethylene glycol) (PEG)-based hydrogels as release systems for nanometer-sized drugs or drug carriers, like nanoparticles, using the radically cross-linkable oligo(poly(ethylene glycol)fumarate) (OPF) together with two cross-linking agents. Different fluorescent nanoparticulate probes with respect to size and physical structure were incorporated in the cross-linked hydrogels, and the obtained release profiles were correlated with the physical properties and the chemical structure of the gels, indicating a strong dependence of the release on the chosen PEG prepolymers. The prepared hydrogels were characterized by oscillatory rheometry and swelling experiments. Release experiments as well as diffusion measurements using fluorescence recovery after photobleaching showed the great potential of this type of hydrogels for the preparation of adjustable release systems by altering the molecular weights of the used PEG molecules.
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