BK通道
伊比利亚毒素
谷氨酸受体
粘菌毒素
化学
钾通道
药理学
细胞生物学
生物化学
生物物理学
生物
受体
作者
Bogusz Kulawiak,Adam Szewczyk
出处
期刊:Mitochondrion
[Elsevier]
日期:2012-01-01
卷期号:12 (1): 169-172
被引量:17
标识
DOI:10.1016/j.mito.2011.12.001
摘要
In the present study, we show that the large conductance calcium-activated potassium channel (BK(Ca) channel) inhibitor paxilline protects neuronal cells against glutamate-induced cell death. In our studies, we used HT22 mouse hippocampal cells as an experimental model and observed that the effect of paxilline was dose-dependent. We also found that other inhibitors of BK(Ca) channels, iberiotoxin and charybdotoxin, were not cytoprotective. Paxillinol, which is a structural analog of paxilline but does not inhibit BK(Ca) channel, also protected HT22 cells against glutamate-induced toxicity. These data suggest that the observed cytoprotection was not related to BK(Ca) channel inhibition by paxilline. In addition, paxilline neither restored glutathione levels nor reduced the amount of reactive oxygen species upon glutamate treatment. Our results suggest that paxilline protects neuronal HT22 cells against glutamate-induced cell death independently of BK(Ca) channel activity and oxidative stress induced by glutamate treatment.
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