壳聚糖
矿化(土壤科学)
活性氧
化学
成骨细胞
抗氧化剂
碱性磷酸酶
生物化学
骨钙素
细胞
细胞生物学
生物物理学
核化学
体外
化学工程
生物相容性
活力测定
MTT法
酶
生物
氮气
有机化学
作者
Jianwen Hou,Qian Li,Jian-Ming Kou,Cui-Wen Zhang,Jia Xuejun,Wei Tian
标识
DOI:10.1016/j.ijbiomac.2014.10.012
摘要
In the present study, water-soluble chitosan (WSC) was prepared by hydrolysis of chitosan with commercial α-amylase, and the effect of WSC on osteoblast function, i.e. alkaline phosphatase activity (ALP), cell viability, mineralization, and reactive oxygen species (ROS) in osteoblastic MC3T3-E1 cells was investigated. Osteoblastic MC3T3-E1 cells were cultured in various concentrations of WSC solutions (1-5 mg/mL) for designated time and then the ALP, cell viability, mineralization, and ROS in the cells were evaluated. Treatments of osteoblastic with WSC caused a significant increase in ALP, cell viability, and mineralization in osteoblastic MC3T3-E1 cells. Moreover, treatments of osteoblastic with WSC decreased ROS level in osteoblastic MC3T3-E1 cells. The results demonstrate that the WSC may reduce or prevent osteoblasts degeneration through antioxidant activity.
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