卡马西平
不利影响
狂躁
剂量
医学
心情
双相情感障碍
麻醉
随机对照试验
癫痫
立即释放
内科学
药理学
精神科
作者
Rif S. El‐Mallakh,Mary Ruth Salem,Amarjit Chopra,Gregory J. Mickus,Praveen Penagaluri
出处
期刊:International Clinical Psychopharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2009-04-01
卷期号:: 1-1
被引量:3
标识
DOI:10.1097/yic.0b013e328329b199
摘要
In epilepsy, slow-release formulations of carbamazepine (CBZ) have fewer adverse events (AEs) compared with immediate-release (IR) formulations. As CBZ is used for mania, it is important to determine whether a similar pattern exists for bipolar patients. This was a 3-month, blinded, random-assignment study to an IR formulation or extended-release carbamazepine capsules (ERCC, Equetro) in type I or type II bipolar patients already on CBZ or clinically determined to benefit from it. Dosages were titrated to patients' clinical needs. Mood and AE ratings were performed at baseline and monthly for 3 months. There was no difference in mood ratings or in the total level of AEs in patients receiving IR or ERCC. However, autonomic AEs (5.0+/-1.1 vs. 2.0+/-0.7, P = 0.02) and gastrointestinal AEs (1.6+/-0.4 vs. 0.6+/-0.3, P = 0.05) were significantly less in participants receiving ERCC. CBZ level in patients receiving ERCC were higher (9.2+/-1.7 vs. IR 7.2+/-1.3 microg/ml, P = 0.005). Total AE load was directly related to CBZ level only in participants receiving the IR formulation. In conclusion, ERCC is better tolerated than IR CBZ in bipolar patients.
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