白质
内囊
胼胝体
部分各向异性
磁共振弥散成像
外囊
神经影像学
医学
萧条(经济学)
心理学
重性抑郁障碍
磁共振成像
内科学
心脏病学
神经科学
心情
精神科
放射科
宏观经济学
经济
作者
Wenbin Guo,Lei Feng,Jindong Chen,Xijia Xu,Renrong Wu,Chaoqiong Ma,Keming Gao,Changlian Tan,Xiaochuan Sun,Changfu Xiao,Huafu Chen,Jingping Zhao
标识
DOI:10.1016/j.pnpbp.2012.03.012
摘要
The association between alterations of the white matter (WM) integrity in brain regions and mood dysregulation has been reported in major depressive disorder (MDD). However, there has never been a neuroimaging study in patients who have treatment-resistant depression (TRD) and are in a current treatment-resistant state. In the present study, we used diffusion tensor imaging (DTI) with tract-based spatial statistics (TBSS) method to investigate the WM integrity of different brain regions in patients who had TRD and were in a current treatment-resistant state. Twenty-three patients with TRD and Hamilton Rating Scale total score of ≥ 18 and 19 healthy controls matched with age, gender, and education level to patients were scanned with DTI. Thirty 4 mm thick, no gap, contiguous axial slices were acquired and fractional anisotropy (FA) images were generated for each participant. An automated TBSS approach was used to analyze the data. Voxel-wise statistics revealed that patients with TRD had lower FA values in the right anterior limb of internal capsule, the body of corpus callosum, and bilateral external capsule compared to healthy subjects. Patients with TRD did not have increased FA values in any brain regions compared to healthy subjects. There was no correlation between the FA values in any brain region and patients' demographics and the severity of illness. Our findings suggest the abnormalities of the WM integrity of neuronal tracts connecting cortical and subcortical nuclei and two brain hemispheres may play a key role in the pathogenesis of TRD.
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