安非雷古林
排卵
内科学
内分泌学
皮调节素
旁分泌信号
卵泡抑素
表皮生长因子
促黄体激素
毛囊
生物
卵泡
生长因子
卵母细胞
自分泌信号
刺激
细胞生物学
受体
激素
医学
胚胎
作者
Jy-Young Park,You‐Qiang Su,Miyako Ariga,Evelyn Law,S.-L. Catherine Jin,Marco Conti
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2004-01-30
卷期号:303 (5658): 682-684
被引量:958
标识
DOI:10.1126/science.1092463
摘要
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
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