A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: Comparison with morphometric studies

HepatologyVolume 20, Issue 2 p. 349-355 Original ArticleFree Access A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: Comparison with morphometric studies Dr. Michéle Chevallier, Corresponding Author Dr. Michéle Chevallier Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Unité de Pathologie Cellulaire, CNRS URA 1459, Institut Pasteur de Lyon, Avenue Tony Garnier, F-69365 Lyon Cedex 07, France===Search for more papers by this authorSylviane Guerret, Sylviane Guerret Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Search for more papers by this authorPhilippe Chossegros, Philippe Chossegros Service d'Hépato-gastroentérologie, Hǒtel Dieu, F-69288 Lyon Cedex 02, FranceSearch for more papers by this authorFrançoise Gerard, Françoise Gerard Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Search for more papers by this authorJean-Alexis Grimaud, Jean-Alexis Grimaud Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Search for more papers by this author Dr. Michéle Chevallier, Corresponding Author Dr. Michéle Chevallier Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Unité de Pathologie Cellulaire, CNRS URA 1459, Institut Pasteur de Lyon, Avenue Tony Garnier, F-69365 Lyon Cedex 07, France===Search for more papers by this authorSylviane Guerret, Sylviane Guerret Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Search for more papers by this authorPhilippe Chossegros, Philippe Chossegros Service d'Hépato-gastroentérologie, Hǒtel Dieu, F-69288 Lyon Cedex 02, FranceSearch for more papers by this authorFrançoise Gerard, Françoise Gerard Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Search for more papers by this authorJean-Alexis Grimaud, Jean-Alexis Grimaud Unité de Pathologie Cellulaire, Institut Pasteur de Lyon, F-69365 Lyon Cedex 07Search for more papers by this author First published: August 1994 https://doi.org/10.1002/hep.1840200213Citations: 184AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The evaluation of hepatic fibrosis on histological sections is of great interest for the staging and follow-up of chronic liver disease. Because no reliable scoring system is yet available, we have designed a semiquantitative scoring system in which the four main sites of fibrotic deposit — centrilobular vein, portal tract and perisinusoidal space, together with width and number of septa when present — are analyzed. These different items have been previously settled from comparison with morphometric measurements to evaluate surface density of total collagen performed on the same liver needle biopsy specimens stained with picro-sirius. The score has been tested on samples from 200 consecutive patients with various liver diseases and compared with the surface density of total collagen and Knodell scoring system. For observer variation study, the features by three independent pathologists were coded on 20 cases. There was a good interobserver (Kendall's τ-B=0.75) and intraobserver (τ-B=0.73) reproducibility. Each component of the fibrosis scoring system and total collagen surface density were significantly linearly related (one-way polynomial analysis, p<10−4); the correlation between semiquantitative scoring system and surface density of total collagen was 0.73 (p<10−5). Our semiquantitative scoring system, simple and reproducible, describes both liver architecture and fibrotic deposit. It is better related to morphometric measurement of fibrosis than each of its constituents or than the fibrosis item of the Knodell scoring system. It represents a reliable and convenient method for fibrosis evaluation, which is mandatory for clinical use. (Hepatology 1994;20:349–355.) Citing Literature Volume20, Issue2August 1994Pages 349-355 ReferencesRelatedInformation