诱导多能干细胞
重编程
胚芽层
生物
肌营养不良
肌营养不良蛋白
杜氏肌营养不良
核型
突变
肌肉无力
干细胞
细胞生物学
遗传学
解剖
基因
胚胎干细胞
染色体
作者
Xinbo Ji,Yu Wang,Ping Sun,Dongdong Wang,Xiaohan Sun,Rui Zhang,Jingwen Xu,Wei Li,Fuchen Liu,Chuanzhu Yan
标识
DOI:10.1016/j.scr.2022.102794
摘要
Becker muscular dystrophy (BMD), an X-linked recessive disorder caused of mutation in the dystrophin gene, is characterized by progressive muscle degeneration and proximal muscle weakness. We generated a human induced pluripotent stem cell (hiPSC) line from the fibroblasts isolated from patient with BMD by non-integrating reprogramming methods. The iPSC line highly expresses pluripotency markers, displays the normal karyotype and is able to differentiate into the three germ layers in vitro. The iPSC line will be a useful tool to study the pathogenesis of BMD and for drug screening.
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