炎症性肠病
免疫学
医学
炎症性肠病
疾病
炎症
克罗恩病
病理
作者
Quan Lu,Meifeng Yang,Yujie Liang,Jing Xu,Haoming Xu,Yuqiang Nie,Lisheng Wang,Jun Yao,De‐Feng Li
摘要
As a main digestive organ and an important immune organ, the intestine plays a vital role in resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction remains important pathogenesis of inflammatory bowel disease (IBD). In this review, we explained the interactions among symbiotic flora, intestinal epithelial cells, and the immune system, clarified the operating mechanism of the intestinal immune system, and highlighted the immunological pathogenesis of IBD, with a focus on the development of immunotherapy for IBD. In addition, intestinal fibrosis is a significant complication in patients with long-term IBD, and we reviewed the immunological pathogenesis involved in the development of intestinal fibrogenesis and provided novel antifibrotic immunotherapies for IBD.
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