N-Hydroxysuccinimide

[6066-32-6] C4H5NO3 (MW 115.10) InChI = 1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2 InChIKey = NQTADLQHYWFPDB-UHFFFAOYSA-N (activating agent for carboxylic acids in amide synthesis and related coupling reactions; acyl transfer reagent) Alternate Name: HOSu. Physical Data: mp 96–98 °C (99–100 °C). Solubility: sol H2O, DMF, alcohols, EtOAc; insol cold ether. Form Supplied in: colorless crystalline solid, widely available. Preparative Methods: by heating Succinic Anhydride with Hydroxylamine or, better, hydroxylamine hydrochloride followed by crystallizations from ether, 1-butanol, and finally EtOAc.1 Purification: can be crystallized from 1-butanol, EtOAc, or EtOH–EtOAc.