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Web ExclusivesJuly 2022Annals for Hospitalists Inpatient Notes - Understanding the 2021 Surviving Sepsis Campaign Guidelines Recommendations on Fluid Resuscitation in SepsisElizabeth S. Munroe, MD and Hallie C. Prescott, MD, MScElizabeth S. Munroe, MDDepartment of Medicine, University of Michigan, Ann Arbor, Michigan (E.S.M.)Search for more papers by this author and Hallie C. Prescott, MD, MScDepartment of Medicine, University of Michigan, and VA Center for Clinical Management Research, Ann Arbor, Michigan (H.C.P.).Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M22-1679 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A 65-year-old man presents to the emergency department with fever, chills, pleuritic chest pain, and productive cough. He has stage 3 chronic kidney disease and heart failure with a left ventricular ejection fraction of 45% to 50%. He is confused, with crackles in the right lung base, dry mucus membranes, and warm extremities. Vital signs are blood pressure of 86/48 mm Hg (mean arterial pressure of 61 mm Hg), heart rate of 120 beats/min, respiratory rate of 28 breaths/min, and Spo2 of 93% on 2 L of oxygen. His chest radiograph shows a dense right lower lobe infiltrate. His laboratory ...References1. Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;49:e1063-e1143. [PMID: 34605781] doi:10.1097/CCM.0000000000005337 CrossrefMedlineGoogle Scholar2. Liu VX, Morehouse JW, Marelich GP, et al. Multicenter implementation of a treatment bundle for patients with sepsis and intermediate lactate values. Am J Respir Crit Care Med. 2016;193:1264-70. [PMID: 26695114] doi:10.1164/rccm.201507-1489OC CrossrefMedlineGoogle Scholar3. Hammond NE, Zampieri FG, Di Tanna GL, et al. Balanced crystalloids versus saline in critically ill adults—a systematic review with meta-analysis. NEJM Evid. 2022;1. doi:10.1056/EVIDoa2100010 CrossrefGoogle Scholar4. Zampieri FG, Machado FR, Biondi RS, et al; BaSICS investigators and the BRICNet. Association between type of fluid received prior to enrollment, type of admission, and effect of balanced crystalloid in critically ill adults: a secondary exploratory analysis of the balanced solutions in intensive care (BaSICS) study. Am J Respir Crit Care Med. 2022. [PMID: 35349397] doi:10.1164/rccm.202111-2484OC CrossrefMedlineGoogle Scholar5. Pancaro C, Shah N, Pasma W, et al. Risk of major complications after perioperative norepinephrine infusion through peripheral intravenous lines in a multicenter study. Anesth Analg. 2020;131:1060-1065. [PMID: 32925324] doi:10.1213/ANE.0000000000004445 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Department of Medicine, University of Michigan, Ann Arbor, Michigan (E.S.M.)Department of Medicine, University of Michigan, and VA Center for Clinical Management Research, Ann Arbor, Michigan (H.C.P.).Disclaimer: This manuscript represents the views of the authors and does not necessarily represent the views of the U.S. Department of Veterans Affairs, the U.S. government, or any other organization to which the authors are affiliated. This material is the result of work supported with resources and the use of facilities at the Ann Arbor VA Medical Center.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M22-1679.Corresponding Author: Elizabeth S. Munroe, MD, University of Michigan, 1500 East Medical Center Drive, 3916 Taubman Center, SPC 5360, Ann Arbor, MI 48109-5360; e-mail, [email protected]umich.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnals for Hospitalists - July 2022 Megan Mack , Matthew Luzum , and David H. Wesorick Metrics July 2022Volume 175, Issue 7Page: HO2-HO3KeywordsSepsis ePublished: 19 July 2022 Issue Published: July 2022 Copyright & PermissionsCopyright © 2022 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...