白藜芦醇
荟萃分析
医学
科克伦图书馆
随机对照试验
纤维蛋白原
纤溶酶原激活物抑制剂-1
内科学
科学网
纤溶酶原激活剂
药理学
作者
Nazanin Mohammadipoor,Fatemeh Shafiee,Amirabbas Rostami,Mohammad Saeed Kahrizi,Hamid Reza Soleimanpour‐Lichaei,Majid Ghodsi,Mohammad Javed Ansari,Dmitry Olegovich Bokov,Behrooz Jannat,Erfan Mosharkesh,Mohammad Sadegh Pour Abbasi
摘要
We perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to quantify the effect of resveratrol supplementation on endothelial function. A comprehensive search was performed in electronic databases including PubMed, Scopus, Web of Science, and Cochrane Library up to February 2021 with no limitation in time and language. A meta-analysis of eligible studies was performed using a random-effects model to estimate the pooled effect size of flow-mediated dilation (FMD), intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1). In total, 21 arms from 17 studies were included. The meta-analysis results showed that resveratrol significantly change the concentrations of FMD (WMD: 1.43%; 95% CI: 0.98 to 1.88, p < .001) and ICAM-1 (WMD: -7.09 ng/ml, 95% CI: -7.45 to -6.73, p < .001). However, VCAM-1, fibrinogen, and PAI-1 did not change significantly after resveratrol supplementation. In conclusion, the results of this study suggest that resveratrol supplementation can improve endothelial function which could be important, especially in patients with cardiovascular diseases.
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