肝细胞癌
医学
恶性肿瘤
乙酰唑胺
肝硬化
肿瘤微环境
免疫抑制
内科学
胃肠病学
癌症研究
肿瘤科
癌症
作者
Andrew Tran,John T. Moon,Jamil Shaikh,Nariman Nezami
标识
DOI:10.1080/13645706.2022.2040535
摘要
Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy. Intra-arterial therapies such as drug-eluting bead transarterial chemoembolization (DEB-TACE) can be effective forms of locoregional treatment for HCC. Solid liver tumors such as HCC promote a biochemical tumor microenvironment (TME) that allows tumor recurrence. The TME creates an environmental acidic pH, which induces chemotherapy resistance and immunosuppression. To address TME acidity, pharmacological agents like acetazolamide could be combined with primary transarterial therapies to optimize HCC treatment. We present a case of a 51-year-old male with a history of alcoholic cirrhosis and recently diagnosed HCC who underwent DEB-TACE with acetazolamide, resulting in complete tumor response on 1.5, 4.5, and 7.5 months follow-up.
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