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Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review

生殖毒性 纳米毒理学 毒性 体内 支持细胞 药理学 精子 氧化应激 生物 化学 医学 毒理 内科学 内分泌学 精子发生 男科 生物技术
作者
Graziela de P.F. Dantas,Fausto S. Ferraz,Lídia M. Andrade,Guilherme Mattos Jardim Costa
出处
期刊:Chemico-Biological Interactions [Elsevier]
卷期号:363: 110023-110023 被引量:19
标识
DOI:10.1016/j.cbi.2022.110023
摘要

The use of nanoscale materials for different biomedical applications has grown a lot in the last years and raised several concerns about toxic effects on human health. Several studies have shown that different types of NPs may exert toxic effects on organs such as the brain, the liver and the kidney. However, The toxicological effects of inorganic NPs on reproductive organs only recently has attracted attention. This systematic review selected data published in the last twelve years assessing rodent-male in vitro and in vivo reproductive toxicity caused by different types of inorganic nanoparticles (AgNPs, AuNPs, IONPs, ZnONPs, TiO2NPs and NiNPs). Structural and functional alterations were commonly observed in Sertoli, Leydig, germ and sperm cells in vitro and in vivo. Oxidative stress, apoptosis, and/or necrosis were the most common findings after inorganic nanoparticle exposure. The toxicity of different NPs depends strongly on their physicochemical characteristics and intrinsic properties. Although a broad overview of the toxicity of different inorganic NPs was found in the papers evaluated, the results are highly variable due to the lack of standardization of protocols, regarding NPs sizes, concentration/doses, and routes of administration. Despite focusing on the effect of different nanoparticles on male reproduction, the mechanisms and pathways related to cellular and/or organ toxicity were poorly discussed. Understanding the specific molecular interactions between NPs and male testicular cells is crucial for developing nanobiotechnologies related to reproductive medicine.
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