Effect of high quality dietary fiber of Hericium erinaceus on lowering blood lipid in hyperlipidemia mice

The purpose of this work is to describe the structure and hypoglycaemic activity of high-quality Hericium erinaceus dietary fiber (HQ-HDF), and compared with the H. erinaceus dietary fiber (HDF). Scanning electron microscopy and particle size distribution showed that the ultrasonic-microwave assisted enzymatic method significantly changed the surface structure of HQ-HDF and reduced the particle size. The results of high-performance gel chromatography showed that the ultrasonic-microwave assisted enzymatic method made the macromolecular components degrade into small molecular components. HQ-HDF has significantly improved hyperlipidemic activity in vitro. The results showed that HQ-HDF has blood lipid-lowering. The levels of total cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein in serum of high-fat mice in medium and high dose group were significantly increased. High dose of HQ-HDF significantly decreased the activities of glutamic-pyruvic transaminase and glutamic oxalacetic transaminase, increased the activities of superoxide dismutase and glutathione peroxidase. High dose of HQ-HDF could decreased the content of malonaldehyde. In addition, histopathological observation of mice liver showed that HQ-HDF could improve the lipid metabolism disorder of liver cells.