Treatment of stable nonsegmental vitiligo using transdermal delivery of 5‐fluorouracil by fractional CO2laser versus intralesional injection of 5‐fluorouracil, both followed by narrow‐band type ultraviolet B (UVB): A comparative study

白癜风 医学 氟尿嘧啶 副作用(计算机科学) 透皮 皮肤病科 外科 化疗 药理学 计算机科学 程序设计语言
作者
Lamia Hamouda Elgarhy,Rania Ahmed El‐Tatawy,Dareen M. Ali,D. M. Abo Anber,Yara Ayman Iskandarani,Mayada Ismail
出处
期刊:Journal of Cosmetic Dermatology [Wiley]
卷期号:21 (9): 3832-3841 被引量:4
标识
DOI:10.1111/jocd.14691
摘要

Updates of treatment methods of stable vitiligo are needed to give better outcomes with a shorter duration of treatment.To test the effect of transdermal 5-fluorouracil (5-FU) delivery using fractional CO2 (FrCO2 ) laser versus intralesional 5-FU injection, with narrow-band type ultraviolet B (UVB) (NB-UVB) therapy after both, in the treatment of stable vitiligo.The present study comprised 40 patients with nearly symmetrical stable vitiligo lesions. The left side was treated with FrCO2 laser followed by topical 5-FU (FrCO2 + 5-FU), while the right side was treated with 5-FU intradermal injection. Both procedures were done at 2-week intervals for 3 sessions followed by 24 sessions of narrow-band UVB for both sides.Repigmentation was demonstrated on the left side of 90% of patients and the right side of 85% of patients. As much as >50% improvement was demonstrated on the left side of 50% of patients, and the right side of 55% of patients. Intralesional 5-FU showed a statistically significant difference in repigmentation compared to FrCO2 + 5-FU.Both 5-FU injection and FrCO2 + 5-FU were effective therapeutic modalities for vitiligo. Patients were more compliant with FrCO2 + 5-FU.
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