光热治疗
磁小体
材料科学
纳米技术
纳米材料
趋磁细菌
磁性纳米粒子
纳米医学
纳米颗粒
磁共振成像
癌症治疗
癌症研究
癌症
磁铁矿
生物
医学
放射科
冶金
遗传学
作者
Peng Ye,Feng Li,Jiale Zou,Ying Luo,Shuang Wang,Guihong Lu,Fan Zhang,Chang Chen,Jiaxin Long,Rongrong Jia,Min Shi,Yugang Wang,Xian Cheng,Guanghui Ma,Wei Wei
标识
DOI:10.1002/adfm.202110063
摘要
Abstract There are several attractive opportunities for using magnetic nanomaterials for anticancer applications. Herein, a magnetic nanomaterial platform is successfully developed based on natural Fe 3 O 4 magnetosomes extracted from the bacterium Magnetospirillum magneticum AMB‐1 for anticancer therapy. The authors initially functionalize the magnetosome membranes in situ with gold nanoparticles to construct an attractive core‐satellite structure. Subsequently, the physical properties and application potentials of these structures are characterized as contrast agents for photoacoustic imaging and magnetic resonance imaging and as therapeutic agents with selective magnetic field guidance for diverse antitumor modalities, including starving, chemodynamic, and photothermal therapies. Owing to the high‐performance imaging‐guided synergistic effect, only a single injection and single laser irradiation result in excellent therapeutic efficacy against tumor growth in multiple cell‐derived xenograft tumor models and, most notably, patient‐derived organoid and patient‐derived xenograft tumor models. The demonstrations of the use of natural magnetic nanomaterials to achieve strong and synergistic antitumor performances highlight the promising application potential of this flexible and easy‐to‐prepare platform for developing innovative treatments for diseases in humans.
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