表观基因组
生物
代谢组
重编程
细胞命运测定
细胞生物学
细胞信号
细胞
体细胞
信号转导
计算生物学
遗传学
生物信息学
代谢组学
DNA甲基化
转录因子
基因表达
基因
作者
Linpeng Li,Keshi Chen,Yi Wu,Xiang Ge,Xingguo Liu
标识
DOI:10.1016/j.jgg.2021.09.006
摘要
Cell fate determination as a fundamental question in cell biology has been extensively studied at different regulatory levels for many years. However, the mechanisms of multilevel regulation of cell fate determination remain unclear. Recently, we have proposed an Epigenome-Metabolome-Epigenome (E-M-E) signaling cascade model to describe the cross-over cooperation during mouse somatic cell reprogramming. In this review, we summarize the broad roles of E-M-E signaling cascade in different cell biological processes, including cell differentiation and dedifferentiation, cell specialization, cell proliferation, and cell pathologic processes. Precise E-M-E signaling cascades are critical in these cell biological processes, and it is of worth to explore each step of E-M-E signaling cascade. E-M-E signaling cascade model sheds light on and may open a window to explore the mechanisms of multilevel regulation of cell biological processes.
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