神经营养素
旁侵犯
黑色素瘤
发病机制
医学
受体
原肌球蛋白受体激酶A
低亲和力神经生长因子受体
病理
谱系(遗传)
神经生长因子
癌症研究
生物
神经科学
内科学
癌症
遗传学
基因
作者
Noah Frydenlund,Meera Mahalingam
标识
DOI:10.1097/pap.0000000000000076
摘要
Desmoplastic melanoma (DM) is a relatively rare cytomorphologic variant of melanoma with a marked propensity for perineural invasion (PNI). Historically, DMs that display PNI have been grouped under the umbrella term of neurotropic melanoma (NM). However, definitions for NM and desmoplastic NM are not consistent in the literature, presenting a barrier to a comprehensive understanding of these lesions. In this review, we parse the literature on DM, NM, and desmoplastic NM, to clarify definitions and ascertain the incidence of PNI, with a view toward understanding its prognostic relevance. Neurotrophins, which represent a family of signaling peptides important to the development and maintenance of the peripheral nervous system, have been implicated in the pathogenesis of PNI in select lineage-unrelated malignancies. Given this, we also detail evidence linking neurotrophins and their receptors (TrkA, RET, p75NGFR, and NCAM) to the pathogenesis of PNI in melanoma.
科研通智能强力驱动
Strongly Powered by AbleSci AI