化学
产量(工程)
环糊精
碱性水解
水解
碱金属
水溶液
质子核磁共振
氢氧化钠
摩尔比
质量分数
甲苯
核化学
反应机理
药物化学
有机化学
无机化学
催化作用
材料科学
冶金
作者
王用良 , 冯茹森 , 郭拥军 , 吕鑫,Wang Yongliang , , Feng Rusen , , Guo Yongjun , , Lv Xin
出处
期刊:Chinese Journal of Applied Chemistry
日期:2011-07-21
卷期号:28 (11): 1269-1273
标识
DOI:10.3724/sp.j.1095.2011.00680
摘要
Employing heterogeneous reaction,6-deoxy-tosyl-β-cyclodextrin(6-OTs-β-CD) was prepared by the reaction of β-CD with p-toluenesulfonyl chloride at low temperature in sodium hydroxide aqueous solution.The compound has been characterized by means of UV-Vis,IR,1H NMR and 13C NMR spectroscopies.The mechanism of cyclodextrin mono tosylation was confirmed by 1H NMR.The effect of hydrolysis factors on product and the influence of reaction conditions on the yield were investigated.Under optimal reaction conditions molar ratio of reactant n(TsCl)∶n(CD)=4∶1,alkali concentration 0.75 mol/L,mass fraction of reactants 4.7%,reaction temperature 0 ℃ and reaction time 5 h,a yield of 43.4% can be obtained.
科研通智能强力驱动
Strongly Powered by AbleSci AI