泛素
蛋白质水解
蛋白酶体
细胞生物学
泛素连接酶
信号转导
蛋白质降解
泛素结合酶
生物
泛素蛋白连接酶类
泛素类
F盒蛋白
生物化学
化学
酶
基因
作者
Aaron Ciechanover,Amir Orian,Alan Schwartz
出处
期刊:BioEssays
[Wiley]
日期:2000-05-01
卷期号:22 (5): 442-451
被引量:762
标识
DOI:10.1002/(sici)1521-1878(200005)22:5<442::aid-bies6>3.0.co;2-q
摘要
The ubiquitin proteolytic system plays an important role in a broad array of basic cellular processes. Among these are regulation of cell cycle, modulation of the immune and inflammatory responses, control of signal transduction pathways, development and differentiation. These complex processes are controlled via specific degradation of a single or a subset of proteins. Degradation of a protein by the ubiquitin system involves two successive steps, conjugation of multiple moieties of ubiquitin and degradation of the tagged protein by the 26S proteasome. An important question concerns the identity of the mechanisms that underlie the high degree of specificity of the system. Substrate recognition is governed by a large family ubiquitin ligases that recognize the substrates, bind them and catalyze/facilitate their interaction with ubiquitin. BioEssays 22:442—451, 2000. © 2000 John Wiley & Sons, Inc.
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