乔丁
生物
诺金
骨形态发生蛋白
BMPR2型
细胞生物学
原肠化
受体
细胞外基质
遗传学
基因
胚胎
胚胎发生
作者
Derek P. Brazil,Rachel H. Church,Satnam Surae,Catherine Godson,Finian Martin
标识
DOI:10.1016/j.tcb.2014.12.004
摘要
Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.
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