组蛋白H2A
组蛋白H4
组蛋白甲基转移酶
SAP30型
乙酰化
组蛋白H1
组蛋白密码
生物
染色质重塑
组蛋白
组蛋白脱乙酰基酶
HDAC4型
组蛋白脱乙酰基酶5
组蛋白乙酰转移酶
HDAC11型
细胞生物学
遗传学
基因
核小体
作者
Jianhua Zhu,Jae Cheol Jeong,Yanmei Zhu,Irina Sokolchik,Saori Miyazaki,Jian‐Kang Zhu,Paul M. Hasegawa,Hans J. Bohnert,Huazhong Shi,Dae‐Jin Yun,Ray A. Bressan
标识
DOI:10.1073/pnas.0801029105
摘要
Histone modification in chromatin is one of the key control points in gene regulation in eukaryotic cells. Protein complexes composed of histone acetyltransferase or deacetylase, WD40 repeat protein, and many other components have been implicated in this process. Here, we report the identification and functional characterization of HOS15, a WD40-repeat protein crucial for repression of genes associated with abiotic stress tolerance through histone deacetylation in Arabidopsis. HOS15 shares high sequence similarity with human transducin-beta like protein (TBL), a component of a repressor protein complex involved in histone deacetylation. Mutation of the HOS15 gene renders mutant plants hypersensitive to freezing temperatures. HOS15 is localized in the nucleus and specifically interacts with histone H4. The level of acetylated histone H4 is higher in the hos15 mutant than in WT plants. Moreover, the stress inducible RD29A promoter is hyperinduced and associated with a substantially higher level of acetylated histone H4 in the hos15 mutant under cold stress conditions. Our results suggest a critical role for gene activation/repression by histone acetylation/deacetylation in plant acclimation and tolerance to cold stress.
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