癌症研究
乳腺癌
细胞
癌症
基因敲除
化学
细胞培养
生物
生物化学
遗传学
作者
Dulamsuren Oktyabri,Akihiko Ishimura,Shoichiro Tange,Minoru Terashima,Takeshi Suzuki
出处
期刊:Biochimie
[Elsevier]
日期:2016-04-01
卷期号:123: 20-31
被引量:37
标识
DOI:10.1016/j.biochi.2016.01.005
摘要
DOT1L is a histone H3 lysine 79 (H3K79) methyltransferase mainly implicated in leukemia. Here we analyzed the function of DOT1L in breast cancer cells. The expression of DOT1L was up-regulated in malignant breast cancer tissues. Over-expression of DOT1L significantly increased the sphere formation and the cell migration activities of MCF7 breast cancer cell line. In contrast, knockdown of DOT1L reduced the cell migration activity of MDA-MB-231 breast cancer cell line. BCAT1, which encodes a branched-chain amino acid transaminase, was identified as one of the target genes controlled by DOT1L through the regulation of H3K79 methylation. Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L-mediated sphere formation and cell migration in breast cancer cells.
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