Exploiting the 1,2,3-Triazole Moiety to Generate Carbazole Molecular Architectures through Click Approach

Reaction of 3,6-dichlorocarbazole with propargyl bromide in the presence of a basic medium gave an N-propargylated carbazole. The latter compound was converted into molecular architectures containing 1,2,3-triazole moiety through Cu(I)-catalyzed 1,3-cycloaddition reaction with different azides. Similarly, 2-azidomethyl benzothiazole was cliched with N-Boc-protected N´-propargyl glutamate to give the biomolecule 2-triazolylmethyl product.