细胞凋亡
幽门螺杆菌
细胞色素c
胃炎
癌症
免疫学
胃粘膜
胃
癌症研究
生物
医学
药理学
内科学
生物化学
作者
Yuan‐Man Hsu,Chih‐Ho Lai,Chiu Hsiang Su,Wei Wen Kuo,Chao-Lin Kuo,Chang-Hung Hsu,Chien Kuo Wang,Ching Yao Chang,Jing‐Gung Chung
出处
期刊:PubMed
日期:2010-04-01
卷期号:30 (4): 1189-93
被引量:7
摘要
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.
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