The 2015 World Health Organization Classification of Lung Tumors

医学 淋巴管平滑肌瘤病 肺癌 错构瘤 病理 腺癌 免疫组织化学 大细胞 癌症 结节性硬化 内科学
作者
William D. Travis,Élisabeth Brambilla,Andrew G. Nicholson,Yasushi Yatabe,John H. M. Austin,Mary Beth Beasley,Lucian R. Chirieac,Sanja Đačić,Edwina Duhig,Douglas B. Flieder,Kim R. Geisinger,Fred R. Hirsch,Yuichi Ishikawa,Keith M. Kerr,Masayuki Noguchi,Giuseppe Pelosi,Charles A. Powell,Ming‐Sound Tsao,Ignacio I. Wistuba
出处
期刊:Journal of Thoracic Oncology [Elsevier BV]
卷期号:10 (9): 1243-1260 被引量:3671
标识
DOI:10.1097/jto.0000000000000630
摘要

The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification. The most significant changes in this edition involve (1) use of immunohistochemistry throughout the classification, (2) a new emphasis on genetic studies, in particular, integration of molecular testing to help personalize treatment strategies for advanced lung cancer patients, (3) a new classification for small biopsies and cytology similar to that proposed in the 2011 Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, (4) a completely different approach to lung adenocarcinoma as proposed by the 2011 Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification, (5) restricting the diagnosis of large cell carcinoma only to resected tumors that lack any clear morphologic or immunohistochemical differentiation with reclassification of the remaining former large cell carcinoma subtypes into different categories, (6) reclassifying squamous cell carcinomas into keratinizing, nonkeratinizing, and basaloid subtypes with the nonkeratinizing tumors requiring immunohistochemistry proof of squamous differentiation, (7) grouping of neuroendocrine tumors together in one category, (8) adding NUT carcinoma, (9) changing the term sclerosing hemangioma to sclerosing pneumocytoma, (10) changing the name hamartoma to "pulmonary hamartoma," (11) creating a group of PEComatous tumors that include (a) lymphangioleiomyomatosis, (b) PEComa, benign (with clear cell tumor as a variant) and
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