喹啉酮
化学
芳基
苯甲醛
乙醇
立体化学
组合化学
碳-13核磁共振
质子核磁共振
有机化学
催化作用
烷基
作者
Xingwen Gao,Xue-Jian Cai,Kai Yan,Baoan Song,Lili Gao,Zhuo Chen
出处
期刊:Molecules
[MDPI AG]
日期:2007-12-27
卷期号:12 (12): 2621-2642
被引量:59
摘要
A simple and general method has been developed for the synthesis of various4(3H)-quinazolinone derivatives by the treatment of the appropriate 3-amino-2-aryl-4(3H)-quinazolinone with a substituted benzaldehyde in ethanol. The structures of the compoundswere characterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. The title 2-aryl- or 2-methyl-3-(substituted-benzalamino)-4(3H)-quinazolinone compounds III-1~III-31 were found to possess moderate to good antiviral activity. Semi-quantitative PCR andReal Time PCR assays were used to ascertain the target of action of compound III-31against TMV. The studies suggest that III-31 possesses antiviral activity due to inductionof up-regulation of PR-1a and PR-5, thereby inhibiting virus proliferation and movementby enhancement of the activity of some defensive enzyme.
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