Modified 5-aminolevulinic acid photodynamic therapy to reduce pain in the treatment of moderate to severe acne vulgaris: A prospective, randomized, split-face study

To the Editor: 5-Aminolevulinic acid photodynamic therapy demonstrates better curative effects with lower recurrence rates and fewer adverse effects than oral isotretinoin in the treatment of moderate and severe acne. 1 Wang X.L. Wang H.W. Zhang L.L. et al. Topical ALA PDT for the treatment of severe acne vulgaris. Photodiagnosis Photodyn Ther. 2010; 7: 33-38 Crossref PubMed Scopus (42) Google Scholar ,2 Wang H.W. Lv T. Zhang L.L. et al. Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of moderate to severe acne vulgaris in Chinese patients. J Cutan Med Surg. 2012; 16: 324-333 Crossref PubMed Google Scholar Because pain is a major concern associated with conventional photodynamic therapy, more effective solutions are needed.