Analysis of Clinical Efficacy of Nano-Albumin Paclitaxel Treatment for Advanced Cell Lung Cancer

紫杉醇 恶心 肺癌 内科学 医学 养生 化疗 顺铂 不利影响 呕吐 肿瘤科 临床疗效 胃肠病学
作者
Xiaoxue Li,Yi Zhang,Xiuyi Zhi,Yuanbo Li,Kun Qian
出处
期刊:Journal of Nanoscience and Nanotechnology [American Scientific Publishers]
卷期号:20 (10): 6019-6025 被引量:5
标识
DOI:10.1166/jnn.2020.18556
摘要

To compare the clinical efficacy and adverse reactions associated with nano-albumin paclitaxel combined with cisplatin and traditional paclitaxel combined with cisplatin for the treatment of non-small cell lung cancer. From December 2016 to August 2019, 78 patients with non-small cell lung cancer in our hospital were randomly allocated into either the observation group (n = 39) or the control group (n = 39). The observation group was treated with nano-albumin combined with cisplatin, and the control group was treated with traditional paclitaxel combined with platinum chemotherapy. After four cycles of treatment, the clinical efficacy and adverse reactions for the two groups were statistically analyzed. Before treatment, there was no statistically significant difference in age, sex, tumor type, and ECOG score between the two groups. After four cycles of treatment, the disease control rate in the observation group was 79.49%, which was significantly higher than that in the control group (38.46%, P <0.05), and the occurrence of myelosuppression, nausea, vomiting, and hyperglycemia in the observation group was significantly lower than that in the control group (P <0.05). Compared with the traditional paclitaxel combined with platinum chemotherapy regimen, the nanoalbumin combined with paclitaxel regimen had significant clinical effect and the adverse reactions were significantly reduced. Thus, it can be considered effective and safe and is suitable for clinical promotion.
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