丝素
自愈水凝胶
生物相容性
海藻酸钠
活力测定
丝绸
组织工程
3D生物打印
细胞包封
材料科学
高分子科学
脚手架
细胞外基质
化学工程
生物医学工程
明胶
生物材料
化学
纳米技术
聚合物
高分子化学
细胞
复合材料
钠
医学
工程类
冶金
生物化学
作者
Truc T. Nguyen,Juthamas Ratanavaraporn,Supansa Yodmuang
出处
期刊:Biomedical Engineering International Conference
日期:2019-11-01
被引量:8
标识
DOI:10.1109/bmeicon47515.2019.8990292
摘要
Bioink design is a big challenge in bioprinting of functional tissues. Bioink serves as extracellular matrix providing structural support and guiding growth and development of tissue. Alginate (SA) and silk fibroin (SF) have been used to create hydrogels due to their excellent biocompatibility and biodegradability. In this study, we investigated printability and cell compatibility of alginate-silk fibroin hydrogels for bioprinting. Different concentrations of SA-SF solution were tested for printability by pushing the mixture through needle and syringe. For Cell compatibility study, osteosarcoma were encapsulated in SA-SF hydrogel, determined cell viability using Live/dead and PrestoBlue™ assay. SA-SF hydrogel containing 1%(w/v) sodium alginate and 2% (w/v) silk fibroin successfully formed uniform strands and supported cell viability. The hydrogel was easy to control mechanical properties by adjusting SA and SF concentrations which could be a tool for studies integrity, printability and mass transport of hydrogels. We demonstrated SA-SF hydrogels has great potential as bioink for use in bioprinter.
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