提吉特
自身免疫
免疫系统
细胞生物学
受体
免疫学
生物
调节性T细胞
人口
癌症研究
T细胞
白细胞介素2受体
医学
遗传学
环境卫生
作者
Liliana E. Lucca,Margarita Dominguez‐Villar
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2020-04-08
卷期号:20 (11): 680-693
被引量:136
标识
DOI:10.1038/s41577-020-0296-3
摘要
Regulatory T (Treg) cells constitute a dynamic population that is essential for controlling immune responses in health and disease. Defects in Treg cell function and decreases in Treg cell numbers have been observed in patients with autoimmunity and the opposite effects on Treg cells occur in cancer settings. Current research on new therapies for these diseases is focused on modulating Treg cell function to increase or decrease suppressive activity in autoimmunity and cancer, respectively. In this regard, several co-inhibitory receptors that are preferentially expressed by Treg cells under homeostatic conditions have recently been shown to control Treg cell function and stability in different disease settings. These receptors could be amenable to therapeutic targeting aimed at modulating Treg cell function and plasticity. This Review summarizes recent data regarding the role of co-inhibitory molecules in the control of Treg cell function and stability, with a focus on their roles and potential therapeutic use in autoimmunity and cancer.
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