生物传感器
材料科学
波导管
纳米技术
药物输送
生物医学工程
光纤
生物相容性材料
毒品检测
光电子学
计算机科学
化学
医学
电信
色谱法
作者
Yuchao Li,Xiaoshuai Liu,Xiaohao Xu,Hongbao Xin,Yao Zhang,Baojun Li
标识
DOI:10.1002/adfm.201905568
摘要
Abstract With great potential in intelligent sensing and actuating systems, biosensors and micromotors are expected to be powerful instruments for early diagnosis and drug delivery in precision medicine. However, it is difficult to ensure the synthetic biosensors and micromotors are compatible with biosystems because of their exogenous building blocks. Biocompatible biosensors and micromotors assembled are reported from living red blood cells (RBCs) optically bound into a waveguide using fiber probes. By monitoring light propagation of the RBC waveguide, the pH of blood solution is detected in real time with an accuracy of 0.05. This can be used for the diagnosis of pH‐related disorders of the blood. After diagnosis, optical torque is exerted on the RBC waveguide, allowing it to rotate as a micromotor and transport microparticles to a target region. The RBC waveguide is then constructed inside zebrafish blood vessels to validate in vivo application. The living biosensors and micromotors are expected to provide a “smart” platform for precise biosensing, medical analysis, and drug delivery.
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