姜黄素
螯合作用
水溶液
质子化
电位滴定法
部分
化学
水溶液中的金属离子
配体(生物化学)
金属
滴定法
配合物的稳定常数
无机化学
核化学
离子
有机化学
立体化学
生物化学
受体
作者
Amerigo Beneduci,Giuseppina Anna Corrente,Tiziana Marino,Donatella Aiello,Lucia Bartella,Leonardo Di Donna,Anna Napoli,Nino Russo,Isabella Romeo,Emilia Furia
标识
DOI:10.1016/j.molliq.2019.111805
摘要
In this work we have studied the complexation of curcumin (HCur, 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) with Al(III) and Fe(III) at 37 °C and in 0.16 M NaCl. The protonation constant of curcumin was also determined to evaluate the competition of the ligand for the metal cations and H+. Speciation profiles obtained by potentiometric titrations show that in aqueous solution a complexation occurs at 1:1 ligand-to-cations ratio. With the aim to define the coordination sites of curcumin with these metal ions a mass spectrometry and UV–Vis spectroscopy characterization was carried out. It was found that aluminum binds to the keto-enol moiety of curcumin, while iron binds to the guaiacol (2-methoxyphenol) one. This unexpected experimental evidence was supported by a thorough computational study.
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